Characteristics of the Byronic Hero

The Byronic hero–so named because it evolved primarily due to Lord Byron’s writing in the nineteenth century—is, according to Peter Thorslev, one of the most prominent literary character types of the Romantic period: Romantic heroes represent an important tradition in our literature . . .. In England we have a reinterpreted Paradise Lost, a number of Gothic novels and dramas . . . the heroic romances of the younger Scott, some of the poetry of Shelley, and the works of Byron. In all of these works the Byronic Hero is the one protagonist who in stature and in temperament best represents the [heroic] tradition in England. Thorslev 189) A Byronic hero exhibits several characteristic traits, and in many ways he can be considered a rebel. The Byronic hero does not possess â€Å"heroic virtue† in the usual sense; instead, he has many dark qualities. With regard to his intellectual capacity, self-respect, and hypersensitivity, the Byronic hero is â€Å"larger than life,† and â€Å"with the loss of his titanic passions, his pride, and his certainty of self-identity, he loses also his status as [a traditional] hero† (Thorslev 187). He is usually isolated from society as a wanderer or is in exile of some kind. It does not matter whether this social separation is imposed upon him by some external force or is self-imposed. Byron's Manfred, a character who wandered desolate mountaintops, was physically isolated from society, whereas Childe Harold chose to â€Å"exile† himself and wander throughout Europe. Although Harold remained physically present in society and among people, he was not by any means â€Å"social. Often the Byronic hero is moody by nature or passionate about a particular issue. He also has emotional and intellectual capacities, which are superior to the average man. These heightened abilities force the Byronic hero to be arrogant, confident, abnormally sensitive, and extremely conscious of himself. Sometimes, this is to the point of nihilism resulting in his rebellion against life itself (Thorslev 197). In one form or another, he rejects the values and moral codes of society and because of this he is often unrepentant by society's standards. Often the Byronic hero is characterized by a guilty memory of some unnamed sexual crime. Due to these characteristics, the Byronic hero is often a figure of repulsion, as well as fascination. Harold Bloom notes that â€Å"[b]etween them, the Brontes can be said to have invented a relatively new genre, a kind of northern romance, deeply influenced both by Byron's poetry and by his myth and personality, but going back also . . . to the Gothic novel and to the Elizabethan drama† (1). When Byron died at the age of thirty-six in 1824, Bronte was but eight years old. Bronte's youthful age, however, did not preclude Byron and his works from having a profound effect on her and her writing; indeed, the â€Å"cult† of Lord Byron flourished shortly after his death â€Å"dominating [the Brontes'] girlhood and their young womanhood† (Bloom 2). Of the Bronte sisters' background, Tom Winnifrith comments that a â€Å"study of the Brontes' juvenilia provides confirmatory evidence of the sisters' preoccupation with the aristocracy, their emancipation from Victorian prudery, and the attraction of the Byronic hero, beautiful but damned† (4).

Duties and Responsibilities in Ones Work Role Essay

1. Describe the duties and responsibilities of own work role As a practitioner, we are obliged to adapt to different sittings for children and young people. Every setting will offer certain benefits and sometimes drawbacks. When working with children and young people, we need to respect the duties and responsibilities of our own work role, The effective practice as a team member will depend on communicating with co workers and heads. One must respect confidentiality of every child and the parents too. You must always put the parents first as the primary care giver of the child. Information concerning a child/children should never be shared or given out to anyone who may ask. Data protection must be respected. Physical punishment must never be implemented upon a child. They are many ways to show that the child’s needs to be corrected. You could use the â€Å"Time Out† system. This is a discipline technique that involves placing children in a boring place for several minutes. There the child will realise that he/she has misbehaved. Time out really means time out from any attention. There could sometimes be cases where the child/children come from different countries hence their different beliefs. We must respect all different beliefs and be careful when working with the kids during activities. One example could be, don’t mention â€Å"pigs† if doing a farm animal activity when a Muslin child is present in class. It could cause problems and upset the specific child/children. This is why, as a practitioner, we must so our homework and make sure cases like this will not arise. This is respecting their customs. All children should be treated equally and never have â€Å"favourites†. When staff meetings take place we must always respect anyone’s contribution and also to other people (outsiders) like social workers, speech therapists, physiologists etc. These people may be very important in the help of any child/children that might have a disability or certain needs. Whenever a child may act in a different way and maybe trying to attract attention, this should not be discarded. It may be that a certain child is abused at home and is reaching out for help. The best thing one should do is to speak to your superior and then to Setha, the abuse centre in Malta, to seek advise as how to go about handling the given situation. All the above mentioned are vital elements to relay duties and responsibilities of our own work role. Once these vital elements are put into practice, we should create a happy, safe environment for the children concerned.

Electronic music Essay Example | Topics and Well Written Essays - 2500 words

Electronic music - Essay Example For instance, if there is a synthesizer voice from an electronic keyboard, then different processes need to be used to create responses. The attack of the synthesizer when it plays the notes and the release which is created is the beginning of this. There are also different ways to manage the voices of the synthesizer to create different effects and sound. Time shifts, delays, resonance and other specialized forms within the music create even more alternatives with the music, all which help to change the way in which the music sounds. The specialty of electronic music is based on the ability to add in the different sounds and special effects. If this is crafted in the right way, then it helps to create a specific reaction from the audience where they catch onto the sounds and accept these as the right approach to the electronic music (Puckette, 15). The challenge that is created with electronic music is to take the techniques and sounds that have been established with the genre and w hich have become popular among audiences. For a new sound to catch with the audience, the production has to use the same sounds or loops and create a different sound and feel. Many of the production artists focus on mixing the same sounds for a different way of making the expression or statement with the music. There are others which change this approach to create different sound production. Inventing new sounds, creating different loops and experimenting with different connections to the electronic music are some of the various ways in which this can be used to develop different sounds and ideologies which are related to the music. The result is the ability to establish a sound that audiences will respond to differently while creating some familiarity with the... This "Electronic music" essay describes the peculiarities of this genre of music. Pop music, classical, jazz and other forms of well – known styles are easily advertised with performances and appearances by famous artists. This is followed by CD advertisements that take place through different settings. Electronic musicians take a different approach than all other genre forms. This is based on the use of electronic mixtures, as opposed to linking to famous and well – known music styles. The approach which most electronic musicians take is to create settings that advertise the music without having to make appearances. Creating CDs, establishing an Internet presence or working with different innovative sounds that are then given to different musicians for advertising are some of the ways that this is used. Electronic musicians usually consider themselves as producers or composers, as opposed to performing artists. This distinction changes the way in which audiences discov er the electronic music and respond to the sounds that are available (Holmes, 337). One of the approaches which have been used with the electronic music genre is the establishment of creative class and the underground social groups that are interested in the music. The social groups that most electronic musicians advertise to are those that are considered off – beat or which belong to social clubs that are out of the mainstream and popular ideas. The social identity that is in the mainstream is attracted more to the performances of genres such as popular music.

How do you use your time Essay Example | Topics and Well Written Essays - 500 words

How do you use your time - Essay Example his situation nudges at family and career values which would place me in a dilemma of making an effort of spending time with family and risking exhaustion before my business meeting. My cousin is earnest but not demanding in his invite. His personal credibility is beyond reproach and he is fair enough in not expecting my full commitment to the occasion. His intention in speaking to me is a motive bound in family values and he does not display any intention aside from inviting me to the occasion. His intention is also persuasive but not insistent. As an audience to his request, the family link played a large part in deciding whether or not I would or should consider his request. He knew that I too was aware of the importance of family and that there were already fewer occasions when the extended family got to gather and mingle with each other. This rhetorical situation revolves around the issue of whether or not I should give time for my family on an otherwise uneventful weekend and risk being too weary for my business travel on the weekday work week; or whether or not I should not join family and friends for a gathering in order to stay refreshed for my business engagement. The main lines of reasoning or argument used in this rhetorical situation are my obligation to family and my duty to my career – to perform at 100% capability during the weekday workweek. My cousin is quick to remind me the value of family, but I would have to make a crucial choice on the situation in a few hours time. My cousin appeals not so much on reason but on my emotions and obligations to my family. He is knowledgeable of the fact that I would really be too tired from travelling to and from the baptism and then again for my business trip. Based on that assessment alone, reason would dictate that I would be compromising the quality of my work when the weekday would come. And he does not bring that logical part of the issue in the conversation. Instead, he appeals to my

Gun control Essay Example | Topics and Well Written Essays - 500 words - 2

Gun control - Essay Example Arguments against gun control include the assumption that possession of a gun would offer protection through self-defense, defense of another, or through scaring an attacker who has a gun. Arguments for gun control however notes that limiting access to guns through regulatory measures is the solution to safety against gun based violence. Your arguments against gun control as a measure to controlling gun-based violence is convincing but has attracted my attention on a number of issues that I believe may not be very true. You offer a rich background of the problem through historical cases of gun based attacks such as the Aurora and Columbine shootings and the battle between proponents and opponents of gun control and this seems to have informed your position of anti-gun control as a solution to controlling gun based violence. I concur with you that the violence is a concern and preventive measures are necessary. Your position that increased level of infiltration may help in managing the rate of violence may further be valid and should not be regarded unless there is sufficient evidence to prove otherwise. I further believe that your conscience to the position of increasing infiltration levels as a solution to gun-based violence is clear and I respect your opinion and desire to save people from gun based attacks (Goldberg 68- 78). Your argument identifies with my opinion that gun based violence is a significant problem in the society and reported cases of public shootings and crimes that are committed with aids of guns supports this. We further share the opinion that a solution that focuses on gun ownership will be the ideal approach to resolving the current problem. The fact that previous efforts to ensure strict policies against gun ownership, experience of people who were affected by Aurora gun incident and reaction from political

Computer forensics Essay Example | Topics and Well Written Essays - 750 words - 1

Computer forensics - Essay Example This research will begin with the definition of computer forensics as a method utilized for the analytical analysis and investigative methods to identify, gather, inspect and preserve information and evidence which is magnetically encoded or stored. Typically computer forensics is used to offer digital evidence of a broad and specific activity in any area of life. Additionally, a forensic analysis is performed for a wide variety of reasons. In the majority of cases, computer forensics is used for the high profile civil litigation or criminal investigation, however digital forensic methods can be of value in a broad range of circumstances, comprising, basically re-tracing steps formulated when information has been lost. Companies that the author has selected for this report are 1) New York Computer Forensics [Web site: Â  http://newyorkcomputerforensics.com]; 2) Guidance Software Professional Services [Web site: http://www.guidancesoftware.com]. New York Computer Forensics Company ha s skilled and expert computer forensic staff and experts. These people effectively utilize the proven methods and sophisticated software, and tools which can be used to analyze and retrieve the entire data on a crime scene system to an absolute level as probable. In this scenario, this kind of material can include deleted files and e-mail and logs and other details that can be related to the problems and issues being examined.

Summary of Anders Stephanson's Global Competition and Manifest Destiny Essay

Summary of Anders Stephanson's Global Competition and Manifest Destiny on the Cusp of the Twentieth Century - Essay Example Notably, America’s imperialism and world power can be dated back to its first endeavors in Asia and the 1899 Open Door policy.   The Open Door policy has for long been identified as a watershed, delimitating a shift in America’s China policy from a de facto â€Å"follower† of British diplomacy to an independent player. This allowed the United States to reap economic, political and religious benefits as well as creating animosity with nations who had interests in China. According to Stephenson, the United States was a latecomer on the international scene and had the zeal to take apart the impediments to entering a geopolitical arena that was dominated by Great Britain. The American interest in China had a typically American flavor, which was the American way. Stephenson seems to show the assertiveness of the American intuition for competition (Gjerde & Elizabeth 104-106). Through the essay, Stephenson shows how the United States acted pragmatically, through undermining the other nation’s attempts in China. The splitting up of China and the jumble for spheres of influence amounted to political aggression as a tactic in power competition, opening up China was also common economic aggression employed by the United States.  

Critical Perspectives on Management and Organizations Essay

Critical Perspectives on Management and Organizations - Essay Example exualization in the workplace as will be covered by this paper is important because although the impulse to desexualize their operations is found to be quite pervasive across most organizations, it has nevertheless been by most people as being an ideal that will essentially never be realized in full. In her article Sullivan (2014) notes that one of the most popular arguments surrounding desexualization was presented by Burrell (1984) who argued that sexual relations generally tend to exist as a dialectic of resistance and control in a situation whereby the active presence of sexual acts and desires generally exist alongside the impulses to control sexuality. This argument as presented by Burrell (1984) is interpreted as meaning that despite the concentrated efforts on the part of our social impulses to try and create what will be a desexualized society, this feat is nevertheless quite impossible and can never be accomplished in its pure form. In his article, Burell (1984) further goes on to call out both the suppression and general expulsion of sexuality as essentially having beein developed as a form of managerial control, in addition to this, Burrell (1984) also suggests that undertaking to implement a re-eroticization experience of labor might potentially have the effect of signifying resistance. This paper is important as it will show the arguments presented by Sullivan (2014) to show that attempts geared at trying to expel sexuality not only from the various individual employees working on organizations, but also from labor, client relations, organizations and occupations has the effect of creating as opposed to helping mitigate some of the ongoing gendered problems. One of the main gendered problems that will be comprehensively analyzed as presented by Sullivan (2004) is that impulses to desexualize organizations and workers tend to as a necessity exist alongside the sexualization of places and bodies. The paper is crucial to this topic as it examines

Performance Appraisal - Bill Blizard's Scenario Assignment

Performance Appraisal - Bill Blizard's Scenario - Assignment Example He wants the problems to be specified precisely so that he may be able to come up with the solutions quickly; however, this attitude sometimes alienates the clients. Bill understands the company’s commitment to use downsized, limited resources wisely, and has separated genuine problems from user-created problems caused by their particular application or â€Å"customization† of the software or their computer â€Å"illiteracy†. He has great expertise in controlling costs; however, this also has alienated some clients who have gone to other vendors than Crystar. Bill lacks people skills. Despite all discussion sessions, goal-setting meetings his employer has had with him, and the one sensitivity training class, he still lacks what needs to come up to the employer’s expectations when it comes to people skills. He did not attend the additional people’s skills seminars that his employer had suggested which shows his lack of flexibility in this specific regard. He does not show interest in those client problems about which he thinks that the client should solve on his own. He cannot handle his attitude in this regard. His roughness, arrogance, and lack of patience are explicit when he deals with non-technical clients. His extreme attempts to control costs have made clients complain about his unresponsiveness and unwillingness to solve what they perceive to be shortcomings in the software. Despite three quarterly reviews, he has only concentrated on his technical skills rather than learning managerial and supervisory skills. Bill needs to redirect his priorities to come up to the employer’s expectations. He needs to learn how to deal with non-technical clients who convey their problems in general terms. He should also learn to hide his frustrations while dealing with customers. He needs to learn how to delegate responsibility and to oversee those who must carry out routine tasks. He must take communication

Around the World in 80 Days & Brave New World Essay

Around the World in 80 Days & Brave New World - Essay Example The advancements that are made in the field of medicine in Huxley’s book as well as its concepts standardization in educational matters present radical similarities to the modern European society as well. These congruenceis are elucidated by Sir Ken Robinson in his discussions on education. Through these scholastic perceptions, it is clearly seen that the book is a hazardously correct prophesy of technology’s capability to control the society, and how this control is silently bringing a change to the values, goals, and moralities, of the European culture (Huxley, 1998). The main themes that are prevalent throughout the Brave New World book, are centered around economic and industrial systems, and how the new technology has influenced the developments of these themes to completion. The society’s mentality is that the progress that is made through invention is the key goal of mankind. Productivism and Consumerism are the meaning of life in Huxley’s industrial ideal place. The consumerist goals of the nation can be obtained by hypnopaedia proverbs that are demonstrated by quote from the book that states that old clothes are beastly and that old clothes are always thrown away. It is better to end rather than to amend (Huxley, 1998). These phrases are found in page fifty-four of the book. It further appeared to be understood that the technological process engine operated most efficiently when individuals are considered of, not as Gods children or indeed as citizens but as users, this is found on page forty-two. This aspect explains with pi npoint precision how the society of Huxley’s operates. Those in the society are no longer determined to believe in god, but rather believe only in the consumption principles (Huxley, 1998). The weaker ranks in Huxley’s community are simple workers who comprise large numbers of drones and one-task intellectuals. The key to the structure of the economy is the mass

Poetry - Alliteration Essay Example for Free

Poetry Alliteration Essay The first poem ‘Sonnet 130’ by William Shakespeare has a humorous view on the traditional ideas of beauty. The poem is a five duplet metre with the stressed sounds starting on the second word of each line. Each line has the same amount of stressed and unstressed patterns which is very common for sonnets to make it quick and easy to read. The five duplet pattern never mimics human speech in the way a four duplet pattern does. The end of each alternating line has a distinct rhyming pattern which goes on throughout the poem. There is also an assonance pattern with each of these words. The first line ‘My mistress’ eyes are nothing like the sun’ shows use of a simile the same as most of the last line ‘I think my love as rare as†¦Ã¢â‚¬â„¢ More use of similes could have been made in the following lines. There is an example of weak alliteration in line eleven ‘I grant I never saw a goddess go’ There is a metaphor in line four when he talks about his mistress’ hair, saying they are ‘black wires’, this view today would be a completely different view from when the poem was written. In our modern time we think of electrical wires coming out of her head. Most of the poem gives negative connotations, the words ‘sun’, ‘red coral’, ‘perfume’ and ‘music’ provides beautiful images. The denotations are her eyes do not shine like the bright sun, her breath ‘reeks’ unlike the smell of perfume and her voice is not pleasant to hear unlike music. The second poem Philip Larkin’s ‘The Trees’ is a twelve line poem that seems to compare the life of a tree to human life. In each stanza the first and fourth line, the end word rhymes with one another along with the second and third last word also rhyming. There is a four duplet pattern with the stressed pattern on the second syllable of each line. Each of these words show a clear assonance pattern with the words ‘thresh’ and ‘afresh’ repeated three times, when spoken aloud almost sound like the wind rustling through the leaves of the tree.

The impact of globalisation in the emerging market economies

The impact of globalisation in the emerging market economies Globalisation is becoming a normal word in todays business environment where different countries are integrating with one another. No country can be self sufficient, they depend on one another. It is very common to see different countries moving from their own nations and invest to other country/countries in order to get markets or resources such as cheap labour. Country boundaries are no longer an issue due to advancement in technology. Globalisation plays a great role on the economical development of different countries in the world especially in the developed countries such as US which has investments in different countries around the global. On the other side of the coin, globalisation has negative impacts on social, cultural, political, technological, environmental as well as economical activities of different countries. The aim of this essay is to assess the impacts of globalisation on the emerging market economies in a double edged-sword, whether it is an opportunity or a threat for their growth. The essay will therefore focus on; what is emerging market economy, characteristics of emerging market economies, the concept of globalisation, its drivers, the impact of globalisation on emerging economies in terms of economic, socio-cultural, environment, technological as well as political-legal and finally make a conclusion of this discussion. LIST OF ACRONYMS FDI Foreign Direct Investments LDCs Less Developed Countries GDP Gross Domestic Product EMEs Emerging Market Economies MNC Multinational Companies UN United Nations IMF International Monetary Fund 1.0 Introduction Over the years it has been witnessed that the aspect of social, cultural, political, technological as well as economical activities of different countries integrating with one another has increased at a rapid rate. The practices that are found in the European countries and the United States are now found in practically at any country in the world. This phenomenon is now commonly referred to as globalisation. Globalisation is not a new phenomenon, for centurys individuals, later companies, institutions and corporations have been trading with each other in locations that are tremendously far from their point of origin. The Asians for example, used the monsoon winds that occurred after a space of six months to move from their countries and reach Africa to trade i.e. buy and sell products to the Africans. China and Europe were also connected during the middle ages through the famed Silk Road across Central Asia. This allowed the two parties to invest to one another which were an aspect of globalisation. This depicts the fact that for a long time globalisation was in existence but not recognised as today as globalisation (Jagdish, 2004). This current situation of the phenomenon of globalisation increasing at a rapid rate has been induced by policies that have opened economies internally (domestically) as well as internationally. One of the main propagators of this was the aftermath of the second world war whereby governments of different countries in the world decided to accept or implement the free market economic system which had an effect on the productive potentials of their countries and generation new opportunities for global trade i.e. the trade was no longer domestic oriented but internationally oriented. This is to say that the policies opened up opportunities for international trade and investments. The Governments have further negotiated the tremendous reductions in barriers to commerce and have established international agreements to promote trade in goods, services, and investments. These have opened up new opportunities in foreign markets and therefore corporations have built foreign factories and estab lished production and marketing arrangements with foreign partners. This is a defining feature of the late trend of globalisation, i.e. it is an international industrial and financial business structure (Jagdish, 1993). The new opportunities have made other countries that had ceased them to be dominant in the Global economy today. Now more than ever, it is a clear picture that the aspect of globalization has been one of the major contributors to the rise in the economic dominance of many economies such as those in the Asian countries i.e. India, china etc. To date china has now integrated with practically every country around that world. The Chinese corporations have come to be so powerful to the extent that the USA is in debt of more that 10bilion dollars to the Chinese banks. The latter is to say that the phenomenon of globalisation has tremendous impacts on emerging economies. This essay will therefore focus on discussing the impact of globalisation in the emerging market economies; in so doing, the essay will focus on defining the emerging market economies, characteristics of the emerging markets, defining the concept of globalisation, drivers of globalisation, and effects of globalisation on emerging market economies in terms of its benefits and drawbacks socially, economically, environmentally and technologically and finally make a conclusion of this discussion. 2.0 Definitions and Concepts 2.1 What is Emerging Market Economy? Emerging market economies are those economies that their economy and industrialisation grow in a rapid pace while experiencing a rapid increase in information efficiency in an environment. These economies are the leaders among developing countries. To be more precise the following are considered to be the leading emerging market economies Brazil, Russia, India, and China, normally referred top as the BRIC countries. The leading one is China due to high growth of its GDP, technology as well as literacy level, about 93.3% of Chinese total population are literate, this became possible since the Chinese government executed its strategy of prioritising education for its people from lower to the higher levels http://en.wikipedia.org. Discussed below will be the characteristics of emerging market economies. 2.2 The Characteristics of Emerging Economies 2.2.1 Transitional The economy of the emerging economies are constantly in transformational process from closed to an open market, trying to stabilise their economic performances for bringing efficiency and transparency in the capital market. Reform in Exchange Rate System International Monetary Fund and World Bank assist the Emerging Market Economies in reforming their exchange rate systems in order to reduce flow of domestic capital to foreign economies since there is an increase of local as well as foreign investments in terms of portfolio and direct. 2.2.3 Attractive to Multinational Corporations The countries in this category are very much on the list of the favourable environments for investment by the MNC because of the ability to provide lower costs of labour and providing a large customer base. 2.2.4 Large Population The first feature of these economies is the population in their country. The emerging economies have a large number of people in their countries as compared to other countries in the world. In the business terms it means they contain a very large share of the consumer base in their own country. China for example is the most populated country ion the world, and India is also one of the single countries that have many people as almost the entire African continent. 2.2.5 High Gross Domestic Product Growth These economies have a remarkable rate of growth on their GDP. China has been estimated to have a 10% growth rate in the last decade. This rate makes it the fastest growing economy in the world and in years to come it may have the leading economy in the world above the United States of America. Much of the growth however had been due to receiving Foreign Direct Investments from the Triads (USA, Japan and Europe), thought in the recent years the BRIC group has also been investing in the Triads. 2.2.6 Changes in Living style The countries with the emerging economies are experiencing an increase in the change in the life style of its population. There is a tremendous change in terms of industrialization, modernisation as well as urbanization. The rural areas are eroding and more cities with tall buildings and many investments are becoming prominent. Some of the wealthiest businesses and business man are found in these emerging economies. Most of the countries populations are more into becoming modern and more urbanised now than years back. Furthermore the standard of living has improved markedly in these emerging economies. Many millions continue to live in poverty but a growing urban middle class provides an expanding market for both domestic products and for imports from abroad. 2.2.7 Volatility of Assets The worlds interest for the assets of the emerging market economies has risen over the past years. The assets of the Emerging economies also tend to become volatile at times, the returns is really worth risking for. The funds of the Emerging economies have also resulted in a much higher percentage of wealth. 2.3 The Concept of Globalisation Globalisation has been a concept narrated for many years by different scholars world wide. Various dimensions come to light when the term globalisation is mentioned. Basically the issue of integration, in terms of the economy, technology, social aspects as well as politics is of highest consideration when one defines globalisation. Globalisation is the system of interaction among the countries of the world in order to develop the global economy. Some scholars have defined globalisation simply as the process of interaction and integration among the people, companies, and governments of different nations, a process driven by international trade and investment and aided by information technology. This process has effects on the environment, culture, political systems, economic development and prosperity, and human physical well-being in societies around the world. Globalisation has been refers to the integration of economics and societies all over the world. Globalisation involves technological, economic, political, and cultural exchanges made possible largely by advances in communication, transportation, and infrastructure (Croucher, 2004). Others however as previously mentioned have defined globalisation as the process of interaction and integration among the people, companies, and governments of different nations, a process driven by international trade and investment and aided by information technology. This process has effects on the environment, on culture, on political systems, on economic development and prosperity, and on human physical well-being in societies around the world http://hubpages.com/hub/Definition-of-Globalization Globalisation attempts to depict the steps by which the networks in the world in terms of communication, transportation and trading cause the linking (integration) of the regional economies, societies, cultures, as well as technologies. At this point in time most of the world is considering the aspect of economic globalisation as one of the single most significant aspect of globalization. With this in mind economic globalization has been separately defined as the linking of economies of different nations to create an international economy via trade, FDIs, Investment cash flows, and the disperse of technology. Globalisation is usually recognized as being driven by the union of the economic, technological, socio-cultural, political, environmental and biological factors. For the purpose of this essay, we therefore define the term globalization as the rapid increase in the interconnectedness of the different countries economically, socially, politically, technologically as well as environmentally to resemble a single village; the process highly being facilitated by the increase in the information and communication technology. 2.4 Drivers of Globalisation. There are many issues that have been discussed when it comes to why is there such an enormous increase in globalisation and why many countries are opening their doors to this phenomenon much easily than before. One of the most common explanation to this has been summarized in one common and yet unique sentence. That is globalisation is inevitable meaning it will occurs, whether one likes it or not it will happen. Never the less that sentence is too short to provide the core drivers of globalisation but rather only explain that the phenomenon is there to stay. The drivers for globalisation can be put into the following categories: Market drivers Cost drivers Technology drivers Governmental drivers Competitive drivers These drivers are better explained below: 2.4.1 Market Driver This actually refers to when the companies consider the various markets to invest. The shifting of the policies of the different governments in the world top having a free market economy has in fact lead to businesses that had a market that was limited to one country to have a global market that waits for the specific products or services that they offer. At this point in companies in different parts of the world have to greater accessibility of the different countries world wide. If there was a trend of no free market economy, the phenomenon of globalization would have been accelerating at a vey small pace and the major transformations will not have been recognized. At this point in time there is the merging of national markets into a singular massive global marketplace. To sell internationally is now easier due to falling of barriers on the cross-border trade. A company doesnt have to be the size of these multinational giants to facilitate and benefit from the globalization of mark ets (Owens 2008) 2.4.2 Production Cost Driver This becomes a driver when it occurs that the costs of production in your country is greater than in another country for the same product, hence it becomes more advantageous for you to produce in another country than in your own. It refers to the sourcing of goods and services from locations around the world to take advantage of national differences in the cost and quality of factors of production. The idea is to compete more effectively offering a product with good quality and low cost. Companies consider the various lifestyle of the country before considering the price of the product and services to render. The companies that find themselves in search for international trade opportunities need to take into account the cost implications associated to where they want to invest. For example one might consider producing certain products in Tanzania than in Europe due to cheaper labour costs etc (Owens 2008) 2.4.3 Technology Driver This actually refers to when there is increasing technology system, transportation, advancing in the level of world trade system. The have been many developments in technology to date and the rate seems unstoppable. These developments or changes in Technological have achieved advances in communication, information processing, and transportation technology, including the Internet and the World Wide Web (www). The most important innovation has been development in the microprocessors after that global communications have been revolutionized by developments in satellite, optical fiber, and wireless technologies, and now the Internet and the World Wide Web. The rapid growth of the internet and the associated World Wide Web is the latest expression of this development. Besides, innovations have occurred in the field of the transportation technology. The development of commercial jet aircraft has reduced the time needed to get from one location to another. Now China is closer to the USA tha n ever (Owens 2008) 2.4.4 Government Driver This refers to the reduction of trade tariffs and non trade tariffs, as a result of reducing the role of political policies. As previously mentioned the adoption of the free market economy has essentially causes the fall of barriers to international trade. Now firms are able to view the entire global as its potential market. The lowering of barrier to trade and investments also allows firms to base production at the optimal location for that activity in order to achieve location economies. A firm might therefore , design a product in one country, create a part/ component parts in two other countries, assemble the product in another country and then export the finished product around the world. The lowering of trade barriers has facilitated the globalisation of production. The evidence also suggests that foreign direct investment is playing an increasing role in the global economy (Croucher, 2004). 2.4.5 Competition Driver The aspect of better products as a result of competition has actually made the aspect of globalisation an essential part in many economies. The competition among companies ensures that there is a production of high quality products globally (Owens 2008) 3.0 The impact of Globalisation on Emerging Market Economies Over the years different debates have existed on whether countries should embrace or be opposed to the phenomenon of globalisation. This debate is pioneered by the likely impact the globalisation has on the various economies or countries in the world. There has been an argument that the aspect of globalisation has favoured already the developed countries while continues to exploit the wealth of developing countries. Below therefore is the discussion on the impact of globalisation on the emerging market economies focused on five main categories; 3.1 Economic impact According to economists, there are a lot of global events connected with globalization and integration. The economy of a nation relies a lot on the business environment that exists. Whether there is high domestic trading or there is a wider range of investments from international companies. Globalisation has enabled the economies of different countries top become integrated. For example, the avenue of international trade now allows countries to have foreign currencies into their economies. Furthermore the aspect of citizens being in one country and owning property in another country is also a reality. The issues of lending has now moved to a whole new level, companies from one country ask for loans from banks in a different country as well as banks of one country can now put branches in other counties which automatically affects the economies. Governments of one nation go and obtain loans from other nations. A typical and yet most amazing scenario is the fact that the American govern ment being in millions of debt to china which is an emerging economy. No doubt globalisation has increased the foreign direct investments in different nations. At this point in time the Mc Donalds company of the United States of America had made a record entry to the Russian and Chinese economy when the policies of these countries had allowed room for the free market economy. The GDP of countries such as china have benefited a lot as a result of globalization. As mentioned earlier chinas GDP has been growing at a rate of 10%, one of the fastest growing rates in the world. 3.2 Socio-cultural Impact Another notable impact of globalisation has been on the culture of various societies in the world. Globalisation has been seen as a catalyst for change in the cultures of less developed countries to be more like those of the developed nations. More specifically it is seen as an imposition of the pop culture (western culture) to other countries. For example the way in which people talk, act, dress etc has changed over the last few decades. The type of music that people listen to globally has changed; even the morals of certain societies have changed. Years back, it was outrageous for women to wear miniskirts in the streets of Arabic countries, but now this is becoming debatable. Even in African countries some aspects are changing. Many people are forgoing their heritage for the new living styles which are believed to be more modernized. Now people believe that if you speak your native language and do not know how to speak English, then you are primitive. All these are a result of globalisation. The way in which people communicate has now also changed. People have conversations via the phone and have reduced the more traditional way of communication which was to visit and see each other physically. No longer are people playing sports outside, they rather play video games, watch movies in the house, all these are a result of globalisation. Furthermore there is a change in the type of ownership in the emerging economies. The aspect of globalisation has introduced a more capitalist system in nations that were primarily involved in communal ownership; the aspect of ownership has become more of individualistic nature. This being the case, there is no longer equal distribution of income among the people of china. This has benefited some of the members who believed that they deserved more for the more work they did but at the same time has created a division among the rich and the poor that was not there in the past. 3.3 Environmental Impact The environment is more of the less discussed factors at times but is ne of the most important aspect that needs to be considered when looking upon the impacts of globalization. The environment basically refers to every thing that surrounds us. In the globalized world more and more business opportunities have emerged for the different businesses in the world as a consequence the businesses that are engaged in manufacturing and involve the emission of harmful substances have increased h=and have caused a destruction in the ozone layer in different parts of the world. Furthermore, the less developed countries have suffered on the environment as the developed countries have used globalization as a means of dumping harmful products from their countries. There had been a ban on several environmentally harmful products in Europe; as a result, the European companies sold the goods to countries like Tanzania etc to not suffer losses. This was a means of dumping their waste products. On the o ther hand though, through globalisation, there are now campaigns all over the world that relate to environmentally protection. International; treaties on environmentally friendly productions have been signed by different nations. The reduction in green house emission treaties have been signed by many nations in the world being led by United states of America and China, the most highly polluting countries in the globe. 3.4 Technological Impact Globalisation has lead to the increase in the spread of technology all over the world. At this point in time, practically all parts of the world are awe-are of the existing technologies every where. The technology that is used in Europe is also used in china and at times even found in Africa. Globalisation has enabled the world to create, modify different technological devices that were founded by some one else in the different part of the globe. The Japanese have been known to modify different technologies that they see existing in the USA. The Chinese are now the ones who imitate all the existing technologies anywhere in the globe. The arena of globalisation has made the latest technologies to exist in every part of the world. Ranging from the latest mobile phones, laptops, video games and all other gadgets, globalisation in one way or the other has ensured that no one is left behind. 3.5 Political-Legal Impact The last aspect that globalization has impacted is on the issue of political and legal environment. Globalisation has been at the centre in the increased international laws that are in existence, the existence on the global organizations that provide principles across the world. The United Nations (UN), the World Bank (WB), the international monetary fund (IMF) and the like. The increased interconnectedness of different counties has enabled the existence of the organizations to crops cut different countries. For example some of the policies in the less developing countries (LDCs) such as the Structural Adjustment Program have been influenced by the World bank, some have been influenced by the united nations etc. This shows how globalization has impacted the political and legal atmosphere of a nation. Country losses its sovereignty in globalization as it is being scrutinized by the international countries. For example all of the countries are now looking at the policies of china and t ry to challenge some of the things that it is doing. In so doing, the sovereignty of the country is being lost (Croucher, 2004). 4.0 Conclusion In general, no one can deny the fact that globalisation is inevitable in todays competitive business environment. The issue is on how the countries take the existence of globalisation. Through in the discussion we saw that there are benefits that are being seen from the existence of the phenomenon, but there are also detrimental effects. All of these depend on the nation and hence the context in which globalisation takes place since each country differs from one another in terms of comparative advantages. There are issues that are related to the loss of a countrys freedom and sovereignty that play a key part on whether to embrace or reject globalisation, nevertheless, globalisation will happen. In a brief overview though one can see that there are many economically related benefits that have been associated with emerging market economies and hence probable cause for the increased acceptance in the phenomenon .The aspects of the expanding sales i.e. where by the emerging economies are having a wider market for its products is a notable reason for the acceptance of globalisation. Now the countries with emerging economies are having the markets in practically in many or any country of the world ranging from Europe to Africa, the Middle East and America. Furthermore, they have now been able to acquire resources such as technology and cheap labour from the various countries that they have invested in. The acceptance in globalisation has also reduced the risks that have been associated with the investment in only their country as there are many fruitful opportunities in other countries. However, in essay 2 critical assessments on the impact of globalisation to the emerging market economies will be discussed by evaluating the positive and negative impacts in particular the culture (socio-culture), economic, technology and environment of China.

Molecular Weight Effect of Different Grades of HPC Polymer

Molecular Weight Effect of Different Grades of HPC Polymer Introduction Bioavailability enhancement Wet media milling + spray drying Issues have impact on dissolution performance Novelty of the work Objective Material and methods wet stirred media milling Spray dryer Characterization techniques Results and discussion Physical stability of the milled precursor suspensions Drug breakage kinetics Formation of the NCMPs via spray drying of the precursor drug suspensions Impact of different polymers on the drug dissolution from NCMPs PVP-K30 HPMC-E3 HPC-SSL, HPC-SL, HPC-L Molecular weight effect of different grades of HPC polymer on drug dissolution performance and stability It is estimated that a large percentage of newly developed drug compounds have limited bioavailibity due to their poor water solubility and very slow dissolution rate [1]. According to the Biopharmaceutics Classification System (BCS), class II drugs are categorized as poorly water soluble and highly permeable in human body [2]. To achieve the therapeutic efficacy of these drugs it is very essential to enhance the bioavailability by increasing the solubility or dissolution rate. A number of approaches have been developed over the time to resolve this issue. The reduction of drug particles size to sub-micron or nanometer has been one of the most popular and effective approaches of all [3-6]. By reducing the particles size order of magnitude, specific surface area of the particles increased radically and enhances the rate of absorption and dissolution [7, 8], according to the Noyes-Whitney equation [9]. Drug nanoparticles production technologies are classified into Bottom-up or Top-down or combination of both. The bottom up techniques include precipitation using supercritical fluid, liquid anti-solvent precipitation, and evaporative precipitation, where small drug particles are produced from drug molecules dissolved in organic solvent [10, 11]. In case of top-down approaches, the particles are reduced to the nanometer range [11]. High pressure homogenization [5] and wet media milling [3] are included in top-down approaches. To prepare drug nanosuspension, wet stirred media milling (WSMM) has achieved the most popularity because of its effectiveness, robustness, scalability, high drug loading, and low polymer side effects [5, 12, 13]. Due to many advantages of drug solid dosage form, it is the most popular dosage form to the patients/clinicians. To encounter this high demand, drug nanosuspensions are usually converted into nanocomposite microparticles (NCMPs) using different drying techniques and incorporated into standard solid dosage forms such as tablets and capsules [13, 14]. Vacuum dryer [15, 16], spray-freeze dryer [17, 18], spray dryer [19, 20], and fluidized bed [17] are very prevalent and widely used drying tools in the pharmaceutical industries. Among all the drying techniques, spray drying has already got attention due to its energy intensive, continuous and scalable drying process characteristics and ability to produce micro to nano-sized particles with a very narrow distribution within a very short time frame [21]. Albeit particle size reduction is an effective technique for bioavailability enhancement, stability issue has always been critical for the efficacy of the drug products. In the nanosuspension, drug particles start losing their specific surface area by aggregation due to relatively high surface energy and specific surface area and also for enhanced Brownian motion [22]. For the prevention of aggregation in the wet media and having better stability, polymers and/or surfactants are added to the suspension as stabilizers. These stabilizers provide stability by electrostatic or electrosteric mechanisms [22]. Steric stability provided by the polymer is drug specific. Only few polymers can help to reduce the particle size of a specific drug down to nanometers. Therefore, selecting a proper stabilizer for a specific drug is a very complex process and cannot be generalized easily [23]. Thus, having a better insight about the polymer properties is very crucial to figure out the right stabilize r for a particular drug. Molecular weight of the polymer is a very significant property of polymers, which determines the capability for steric stabilization along with solution properties [24, 25], regulates mechanical property of the films [26], and controls the drug release during oral administration [27]. Consequently, optimum MW and polymer concentration may help to get the best stabilization performance during and after milling, and faster drug release from the composites.   Choi et al. [16] investigated the impact of lower range MW (11,200-49,000 g/mol) of hydroxypropyl cellulose (HW) on itraconazole suspension production and their recovery from the drug composites. In that work, HPC was used solely with the same concentration, and dissolution performance study was absent.   Sepassi et al. [28] studied MW effect of two different polymers hydroxypropylmethyl cellulose (HPMC) and polyvinylpyrrolidone (PVP) on the particle size reduction of milled nabumetone and ha lofantrine suspensions; however, drying and dissolution rate were not studied. Li et al. [29] studied the MW and concentration effect of hydroxypropyl cellulose (HPC) on the dissolution performance of poorly soluble drug griseofulvin (GF) in presence/absence of sodium dodecyl sulfate (SDS) as surfactant. In that investigation, drug nanosuspension was coated and dried on to the surface of pharmatose using fluidized bed technique and also determined the optimum concentration and MW effect of HPC for complete release of the drug particles during dissolution. To authors best knowledge, no comprehensive and systematic study has been performed so far to get the insight about the head to head comparison of different polymers performance and MW effect of the same polymer on the suspension stability after milling and during dissolution of NCMPs produced via spray drying. It is known from prior study that the combined use of polymers and surfactants provide a synergistic effect leading to better stability in the nanosuspension than individual stabilizers [30, 31]. Due to the side effects of surfactant, it is always expected to use minimal amount in the formulation. If only the use of polymer can provide substantial stability in the nanosuspension and immediate release of the drugs in the dissolution from NCMPs, then it is more viable than using surfactant.   Therefore, this study aims to develop an understanding of the polymer MW and different polymer effect on the physical stability of Itraconazole nanosuspension and drug dissolution fr om the composites. Itraconazole (ITZ) suspensions were milled in a WSMM and the nanocomposite particles were produced using a co-current spray dryer. Three different polymers HPC, PVP, and HPMC were used at 4.5% (w/w) concentration to see the polymer effect and for MW effect, three grades (SSL, SL, and L) of HPC having different MW were used. Laser diffraction, SEM, UV- spectroscopy, XRPD, and DSC were used to analyze the drug suspension and composite particles. Dissolution test of the NCMPs were performed by a USP II paddle apparatus. Materials Itraconazole (ITZ), is an antifungal drug with a water solubility 0.13 mg/L (at pH-7 and 25  °C), is a sparingly water soluble drug belong to the BCS Class II was purchased from Jai Radhe Sales (Ahmedabad, India) and was used as-received condition. Three different polymers, hydroxypropyl cellulose (HPC), hydroxypropylmethyl cellulose (HPMC), and polyvinylpyrrolidone (PVP) were used as polymers. Three grades (SSL, SL, and L) of HPC with ~40, ~100, and ~140 kDa molecular weight, respectively, were donated by Nisso America Inc. (New York, NY, USA) and used for steric stabilization. Polymeric stabilizers Methocel E3 grade HPMC and PVP Kollidon 30 were donated by Dow Chemical (Midland, MI, USA) and BASF Corporation (Florham Park, NJ, USA) respectively. Sodium dodecyl sulfate (SDS) is an anionic surfactant used as a wetting agent during dissolution and provide electrostatic stabilization in the suspension, was purchased from Sigma Aldrich (Milwaukee, WI, USA). Zirmil Y grade wear-re sistant yttrium-stabilized zirconia (YSZ) with a median size of 430  µm (400  µm nominal size) was used as the milling media and purchased from Saint Gobain ZirPro (Mountainside, NJ, USA). Methods Wet Stirred Media Milling (WSMM) The presuspension (before milling) was prepared following the same procedure used in Afolabi et al. [32]. All the suspension formulations are tabulated below in Table 1. API (Itraconazole) concentration was kept constant at 10% (w/w) and polymer concentration was 4.5% (w/w) for all the formulation. All the concentrations are reported with respect to deionized water (200g). The formulation with 2.5% (w/w) HPC-SL and 0.2% (w/w) SDS was used as a baseline formulation, because from earlier study it was found to be the optimum for fastest and complete drug release from the composite powders. Prepared drug suspension was milled in a Netzsch wet media mill (Micorcer, Fine Particle Technology LLC, Exton, PA, USA) with 80 ml chamber; 50 ml of the chamber was filled with 400  µm (nominal size) Zirconia beads, which is the milling media and a screen with 200  µm opening was used to hold the beads into the chamber and allowing only the passage of the suspension. A shear mixer (Fisher Scientific Laboratory Stirrer, Catalog No. 14-503, Pittsburgh, PA) was used to prepare the suspension prior to transfer into the holding tank of the miller. The suspension was pumped through a peristaltic pump and was milled under the following conditions: suspension flow rate 126 ml/min, rotor speed 4000 rpm corresponding to a tip speed of 11.7 m/s. To keep the suspension temperature below 35  °C, milling chamber and holding tank both were equipped with a chiller (Advantage Engineering Greenwood, IN, USA).   All the parameters were selected from the earlier work done by Afolabi et al. [31]. To determine the breakage kinetics, particle sizes were measured at different time intervals up to 65 minutes and the suspension were refrigerated at 8  °C for one day before spray drying. Preparation of NCMPs via Spray Drying The prepared nanosuspesions were dried within a day of milling using a spray dryer (4M8-Trix, Procept, Zelzate, Belgium) running in a co-current flow set up. All the operating conditions were taken from Azad et al. [19].The suspensions were atomized at 2 bar atomizing pressure using a bi-fluid nozzle having 0.6 mm tip diameter. In each run, ~120 gm nanosuspensions were sprayed at 1.3-1.6 g/min spray rate using a peristaltic pump (Makeit-EZ, Creates, Zelzate, Belgium). Drying air was fed co-currently from the top of the column at 120  °C temperature and 0.37-0.40 m3/min volumetric flow rate. To avoid sedimentation of the drug particles during spraying, the suspension was stirred using a magnetic stirrer throughout the run. A Cyclone separator was used at 54-70 mbar differential pressure to separate the NCMPs from the outlet air stream and collecting them in a glass jar. The dried powders later on were used for powder sample characterization e.g., XRD, DSC, Rodos, and dissolutio n testing. Particle Size Analysis Particle size distributions of the suspensions were measured at different time interval during milling and after 7-day storage in the refrigerator by laser diffraction (LD) technique using Coulter LS 13 320 (Beckman Coulter, Miami, FL). All the steps involved for measuring PSDs of the suspensions were followed from Li et al. [29]. During sample addition, intensity was maintained between 40-45% while obscuration was below 8%. Mie scattering theory was used to compute the volume-based PSDs in the software. Refractive index value is 1.68 for ITZ and 1.33 for deionized water (medium). Before measuring the PSDs, 2 ml suspension sample was collected from the outlet of the mill chamber and diluted with 5 ml of the respective stabilizer solution using a vortex mixer (Fisher Scientific Digital Vortex Mixer, Catalog no: 0215370, Model No: 945415, Pittsburgh, PA) at 1500 rpm for 1 min. The Particle size distributions (PSDs) of produced NCMPs via spray drying were measured by Rodos/Helos laser diffraction (LD) system (Sympatec, NJ, USA) based on Furnhofer theory with dry powder dispersion module. On the sample chute of the Rodos dispersing system, just about 1 g of the sample was placed. To feed the samples, the sample chute was vibrated at 50% settings and 0.1 bar dispersion pressure was imposed to suck in the falling powder through the sample cell of the laser diffraction system. Determination of Drug Content in the Composite Powders Drug content of the composite powders were measured by assay testing. ITZ solubility is - in dichloromethane (DCM). 100 mg of the NCMPs was dissolved in 20 ml DCM, sonicated for 30 mins to ensure all the ITZ is dissolved in the solvent and then they were allowed to sediment overnight. An aliquot of 100  µl is taken from the supernatant and diluted to 10 ml with DCM. The absorbance of all the samples was measured at 260 nm wavelength via Ultraviolet (UV) spectrophotometer (Agilent, Santa Clara, CA, USA). Six replicates were prepared from each NCMP formulation to calculate mean drug content and percent relative standard deviation (RSD). Scanning Electron Microscopy (SEM) SEM imaging was performed to understand the morphology and particle size of the ITZ particles before and after milling. SEM images of as-received ITZ and baseline formulation was taken using a LEO 1530 SVMP (Carl Zeiss, Inc., Peabody, MA, USA) SEM machine. Approximately, 0.1 ml milled suspension sample was placed on top of a silicon chip (Ted Pella Inc., Redding, CA, USA), and then on top of a carbon specimen holder. The sample was placed into a desiccator for overnight drying. The samples were then sputter coated with carbon before analyzing [33]. X-ray Powder Diffraction (PXRD) The crystallinity of the as-received ITZ, physical mixture of ITZ-excipinets, and spray dried powders were analyzed using PXRD (PANalytical, Westborough, MA, USA), provided with Cu KÃŽÂ ± radiation (ÃŽÂ »= 1.5406 Ã…). The samples were scanned at a rate 0.165 S-1 for 2ÃŽÂ ¸ ranging from 5 to 40 °. Differential Scanning Calorimetry (DSC) DSC of the as-received ITZ, Physical mixture of ITZ-excipients, and spray dried powders was performed using a Mettler-Toledo polymer analyzer (PolyDSC, Columbus, OH, USA). The samples were heated at a rate of 10  °C/min within a range of 25-220  °C under nitrogen gas flow. With the help of the integrated software of the machine, melting temperature Tm and fusion enthalpy ΆHm were determined. Dissolution Testing Dissolution of ITZ from the as-received drug, and spray dried composite powders were determined via a Distek 2100C dissolution tester (North Brunswick, NJ, USA) according to the USP II paddle method.   The dissolution medium was 1000 ml SDS buffer with 3.0 gm/ml concentration at non-sink condition.   The medium was maintained at 37  °C temperature and 50 rpm paddle speed.   The composites were weighed equivalent to a dose of 20 mg of ITZ. Composites were poured into the dissolution medium and manually 4 ml of samples were taken out at 1, 2, 5, 10, 20, 30, and 60 min. Aliquots of the samples were filtered using a 0.1  µm PVDF membrane type syringe filter to avoid any effect of undissolved drug during UV spectroscopy measurement. The absorbance of ITZ dissolved was measured via UV spectroscopy (Agilent, Santa Clara, CA, USA) at 260 nm wavelength. The blank was measured using SDS buffer at the beginning. The amount of drug dissolved was measured using a calibration curve generated from drug concentration vs. absorbance (R2=0.9995 with p Apparent Shear Viscosity of Milled ITZ Suspensions The apparent shear viscosity of the nanosuspension was measured by following the procedure from Afolabi et al. [32], using R/S plus rheometer (Brookfield Engineering, Middleboro, MS, USA). To impart controlled shear rate on the samples from 0 to 1000 1/s in 60 s, a coxial cylinder (CC40) was used. To control the temperature the jacket temperature was kept constant at 25 ±0.5  °C. Drug nanoparticles formation and physical stability of the milled suspensions The formulation of the milled drug (ITZ) suspensions are presented in Table 1. Drug (ITZ) nano suspension was first produced in presence of both steric and an anionic surfactant, SDS (Run 1). Due to the synergistic effect of HPC and SDS [31], Run 1 was used as a baseline to assess the impact of various stabilizers (HPC, HPMC E3, PVP k30, and SDS) in their breakage kinetics and physical stability of the resulting suspensions. This baseline formulation was found to be the optimum formulation from a previous work performed by Meng et al [29]. The molecular weight effect of HPC was then studied in absence of SDS surfactant (Run 2-4) using three different grades of HPC; SSL, SL, and L grades having molecular weight ~40, ~100, and ~140 kDa, respectively. The apparent shear viscosity of all the formulations (Run 1-7) are represented in Figure 1. Formulations with 2.5% (w/w) HPC-SL/SDS, 4.5% (w/w) HPC-SL, and 4.5% (w/w) HPC-L (Run 1, 3, and 4) are showing near Newtonian behavior, indicating the extent of aggregation is very low. Milled drug suspensions stabilized by SDS or polymer alone (except HPC-SL and HPC-L) are showing significant shear-thinning behavior, indicating significant amount of aggregates. References 1.Kesisoglou, F., S. Panmai, and Y. Wu, Nanosizing-oral formulation development and biopharmaceutical evaluation. Advanced drug delivery reviews, 2007. 59(7): p. 631-644. 2.Amidon, G.L., et al., A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical research, 1995. 12(3): p. 413-420. 3.Merisko-Liversidge, E. and G.G. Liversidge, Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. Advanced drug delivery reviews, 2011. 63(6): p. 427-440. 4.Panagiotou, T. and R.J. Fisher, Form nanoparticles via controlled crystallization. Chemical Engineering Progress, 2008. 104(10): p. 33-39. 5.Keck, C.M. and R.H. 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Ruddy, Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate. 2002, Google Patents. 31.Bilgili, E. and A. Afolabi, A combined microhydrodynamics-polymer adsorption analysis for elucidation of the roles of stabilizers in wet stirred media milling. International journal of pharmaceutics, 2012. 439(1): p. 193-206. 32.Afolabi, A., O. Akinlabi, and E. Bilgili, Impact of process parameters on the breakage kinetics of poorly water-soluble drugs during wet stirred media milling: a microhydrodynamic view. European Journal of Pharmaceutical Sciences, 2014. 51: p. 75-86. 33.Li, M., et al., An intensified vibratory milling process for enhancing the breakage kinetics during the preparation of drug nanosuspensions. AAPS PharmSciTech, 2016. 17(2): p. 389-399.

Moral Split and Respect Essay -- Morality Right Wrong Essays

Moral Split and Respect We will always find ourselves in â€Å"moral split† situations. We struggle to make the right decision and hoping that what we decide would be the correct choice. Sometimes our decisions are strictly depended on the notion of self-filling prophecy while others are for the sake of philanthropy. We are selfish if the chosen actions turn out to be a negative impact on the majority of people; however, the negativity is unforeseeable. If we know ahead of time that our decisions are going to be harmful to others then more likely than not we would have tried to avoid that complication. Then again, life is unpredictable. It is unpredictable just like the Vietnam War. Americans went into the war with culture relativism. They thought the decision to assist in the fighting against communism was the ultimate must. They sent young men blindly into a foreign land and were so positive that it was going to be an ideal outcome. If the Northern Vietnamese was defeated, then it might be a different story; however, the consequences they must face. On the other hand, the Vietnamese had two different perspectives of the war. The Southern Vietnamese believed that the Americans were angels sent from above to rescue them from the communists. The Northern Vietnamese thought that the Americans should mind their own business. We cannot say either views were right or wrong, rather, they were picked from the same moral standards but in different circumstances. The South, America and the North yenned for victory. They made decisions that each one truly believed to be the preeminent; therefore, no sides should be unnecessarily criticized. Similarly to us, they were making the right decisions based on personal valuations of ... ...ting will never â€Å"understand everything [and] would be incomplete forever† (249). The only understanding that these people are left with is the pondering of the possible outcome if they have chosen otherwise; not to fight. If that person truly believes that the war is the only way to solve the problem then that it would be ethically correct for him to be involved because morality is based on a person’s own judgment of what is right and wrong. On the other hand, if a person feels that is it wrong, without a doubt, then it is sad to believe that he chooses to go against his morals. Works Cited Johnson, Brendan B. â€Å"The Movie Quotes Site: The Deer Hunter.† (1997). 6 Dec. 2003 . Dirks, Tim. â€Å"Greatest Films: The Deer Hunter.† (1996). 6 Dec. 2003 â€Å"IMDb: Full Metal Jacket.† (1990). 6 Dec. 2003 â€Å"Amazon.com: Apocalypse Now Redux.† (1996). 6 Dec. 2003

Male and Female Relationships in Generation Y Essay -- Sex Abstinence

Male and Female Relationships in Generation Y Sexual relationships among teenagers today involve not only dating and sexual activity, but also health and lifestyle issues such as sexually transmitted diseases and unwanted pregnancies. Today’s teens are more informed and willing to practice safe sex than previous generations. As a whole, trends like body piercing for sexual pleasure all the way to strict abstinence have been adopted by Generation Y youth (Codrington). Where did it all begin? Heterosexual relationships have existed from the beginning of time, when the God of Christianity created Adam and Eve. Since that time relationships among heterosexual partners have continued to evolve. Instead of fathers arranging to give away their daughters to deserving men, people in America today now chose who they want to have relationships with. Dating and the Attractive Partner Sexual relationships usually begin with dating. Dating is the time when two people get to know each other and a time when they start to consider if they can have a long-term relationship. For today’s teens the new trend in dating is dating in groups of four, six, or even ten people (Stapinski). Even with this new trend however, the men are still asking the woman out. According to Leland Elliott and Cynthia Brantley, authors of Sex on Campus, 77 % of college boys still ask for the first date, while a mere 16 % of college woman take charge (49). Also, most college students (76 %) date only one person at a time. What do both men and woman look for in the opposite sex? If a woman were to answer for a man, most would probably list physical attributes such as eyes, smile, butt, and breasts, but the truth is that the number one thing a man l... ...girls in Jeopardy.† Human Ecology Forum Summer 1997:12+. * Pseudonym, to protect privacy 1 â€Å"Founded in 1916, world’s largest and oldest voluntary family planning organization. It is dedicated to the principles that every individual has a fundamental right to decide when or whether to have a child and that every child should be loved.† (www.plannedparenthood.com) 2 The condom concept dates back to 1350 B.C. when ancient Egyptians figured covering the penis might prevent pregnancy†¦Vulcanized rubber made an appearance as condom material in the mid 1800s. ( Sex on Campus 1997). â€Å"The Trojan brand has been a leader in providing videos and teaching guides for use in high school health education classes across the United States.† (Vogel 33). 3 HIV is an abbreviation for â€Å"Human Immunodeficiency Virus.† This virus is what causes AIDS ( Sex on Campus 1997).

The Effects of Increased Temperature on Fish Reproduction Essay

The Effects of Increased Temperature on Fish Reproduction Today, many factors can contribute to an unexpected increase in temperature in streams, ponds, lakes and even oceans. One of the many factors which may cause this is a nuclear power plant. Although many might think that nuclear power is a source of many pollutants, this has been proven not to be so (1). In fact, nuclear power plants only cause one pollutant to the nearby water bodies, increased temperature. Usually this increase in temperature is approximately ten degrees above normal (2). However, this main study is to look at any effects that fish may have because of this increase in temperature. Several studies have been performed in this area, on several different species of fish. Although most fish respond in the same way, Eurasian Perch, for example, showed interesting side effects. By having an experimental group, which is placed into waters at a temperature of about ten degrees higher than the natural temperature, it is easy to compare to the control group, what physiological problems had occured. During the winter months, fish seek cooler water to perform gametogenesis, that is, sperm and eggs begin to form through meiosis. When spring arrives, these fish head back towards warmer water to spawn (3). What if the temperature is kept at a constant higher than the control group? One could say that this might cause the fish to think it is in the spawning season. By giving the fish a constant spawning season, the fish's reproductive cycle is knocked out of sequence. For example, suppose a fish normally lives in cold water during the winter months. If the fish is suddenly exposed to warm water during this time period, it may cause problems by... ...f the Brown Bullhead, Ictalurus nebulosus, with Reference to its Orientation to the Discharge Canal of a Nuclear Power Plant. F. Paul Richards, Richard M. Ibara Trans. Am. Fish. 1978 107(2), 288-220 Other Works: DNA Damage and Radiocesium in Channel Catfish from Chernobyl Derric w. Sugg, John W. Bickham, Janet A. Brooks, Michael D. Lomakin Environmental Toxicology and Chemistry 1996 Vol. 15, No. 7, 1057-1063 Effects of Temperature on Mitochondrial Function in the Antarctic fish Trematomus Bernacchii R. B. Weinstein, G. N. Somero J. Comp Physiol B. 1998, (168) 190-196 Gonadal Impairment in roach Rutilus rutilus from Finnish Coastal Area of the Northern Baltic Sea Tom Wiklund, Laura Lounasheimo, Jim Lom, Goran Bylund Inter Research 1996, Vol. 26, 163-171 The Effects of Increased Temperature on Fish Reproduction Essay The Effects of Increased Temperature on Fish Reproduction Today, many factors can contribute to an unexpected increase in temperature in streams, ponds, lakes and even oceans. One of the many factors which may cause this is a nuclear power plant. Although many might think that nuclear power is a source of many pollutants, this has been proven not to be so (1). In fact, nuclear power plants only cause one pollutant to the nearby water bodies, increased temperature. Usually this increase in temperature is approximately ten degrees above normal (2). However, this main study is to look at any effects that fish may have because of this increase in temperature. Several studies have been performed in this area, on several different species of fish. Although most fish respond in the same way, Eurasian Perch, for example, showed interesting side effects. By having an experimental group, which is placed into waters at a temperature of about ten degrees higher than the natural temperature, it is easy to compare to the control group, what physiological problems had occured. During the winter months, fish seek cooler water to perform gametogenesis, that is, sperm and eggs begin to form through meiosis. When spring arrives, these fish head back towards warmer water to spawn (3). What if the temperature is kept at a constant higher than the control group? One could say that this might cause the fish to think it is in the spawning season. By giving the fish a constant spawning season, the fish's reproductive cycle is knocked out of sequence. For example, suppose a fish normally lives in cold water during the winter months. If the fish is suddenly exposed to warm water during this time period, it may cause problems by... ...f the Brown Bullhead, Ictalurus nebulosus, with Reference to its Orientation to the Discharge Canal of a Nuclear Power Plant. F. Paul Richards, Richard M. Ibara Trans. Am. Fish. 1978 107(2), 288-220 Other Works: DNA Damage and Radiocesium in Channel Catfish from Chernobyl Derric w. Sugg, John W. Bickham, Janet A. Brooks, Michael D. Lomakin Environmental Toxicology and Chemistry 1996 Vol. 15, No. 7, 1057-1063 Effects of Temperature on Mitochondrial Function in the Antarctic fish Trematomus Bernacchii R. B. Weinstein, G. N. Somero J. Comp Physiol B. 1998, (168) 190-196 Gonadal Impairment in roach Rutilus rutilus from Finnish Coastal Area of the Northern Baltic Sea Tom Wiklund, Laura Lounasheimo, Jim Lom, Goran Bylund Inter Research 1996, Vol. 26, 163-171

Where to use mean, median or mode to make a decision

Measures of average are also called measures of central tendency. Their purpose is to provide a numerical figure which may describe the level of entire distribution. For example let five students be awarded marks as follows. 10, 11,9,12 and 13. All these scores are different from each other but at least there is one such score to which the rest of the scores standby or nearby. There are three measures of central tendency as follows; mean, median and mode (Srivastava et al. , 1989). These are used at different occasions when making a decision for example when the administration of the state is requiring to collect and analyze data related to population and material wealth of the country for the purpose of planning and finance. Mean can be used when making the instructional decisions. This can be used by a teacher to get the knowledge about the student’s entry behavior and background; in this case the distribution should be normal meaning all the scores should be present. By getting the mean of the student’s scores, the teacher will be able to identify the teaching technique to use according to their strengths and weaknesses. Consequently, the mean should be used when the teacher is evaluating the degree to which the objectives have to be achieved so that he/she will be able to encourage good study behavior among the students. Incase the scores are scattered the mean must be used so that all the scores are brought together to enable decision making to take place may be about the performance. Median should be used for guidance decisions. Students should be guided in their vocational choices; educational performance and their personal problems therefore median can be used to determine the average performer in class and can be advised accordingly. At the same time, median is used to make guidance decisions especially when a quick and easily computed measure is required to provide the data about significant characteristics which can help a certain group of people to understand themselves better. Mode should be used in research decisions in the sense that for any research to be carried out there must be collecting of the data on the issue at hand. After collecting the data, scoring, and analysis should be done and interpretation of the whole information given. When the information is incomplete mode must be used. It is also used when one wants to know the fashion of the most recurring measure or score.

Arts

One of these checks novelly preformed was of a 67 year old affected role who presented for a hysterectomy. She ended up with complications and subsequent sermon for these complications, completely stock a crap c ar was provided by nightingale Comm building blocky Hospital. Mistakes were do with this tolerants c atomic number 18 and disciplinal implements principal sum be interpreted. It is cases like these we contact to correct, in array to become the hospital of choice for diligents, employees, physicians, volunteers, and the community. (nightingale Community Hospital, p. ) In order to learn and grow from the mistakes do with our tracer bullet bullet bullet bullet unhurried, we must identify peculiar(prenominal) mistakes made and develop a corrective carry through plan to address the improvements we are issue to make. According to the breeding provided by our tracer patients worksheet, it was determined the patient presented for librarianship hysterectom y that was converted to an rough procedure due to excessive expel approximately five workhebdomads prior to hospitalizing. later on examining our patients worksheet, or fact sheet, a hardly a(prenominal) items throughout their care with us was non up to standards.First mistake found was our tracer patient did not have an admissions mind thin the 24-hour window, starting with the time of admissions. The tracer patients physical was d integrity everywhere 72 hours subsequently admission. Second, the cater incubateed completing a functional perspicacity precisely there was no documentation funding this claim in her map. Third, the control prized the essential for an advance directive, found nvirtuoso to be present, and requested the family add up ace with them. The family never followed through and did not provide it.Fourth, the guards did not update the tracer patients plan of care since the surgery, and this perspicacity was do 5 weeks after surgery upon re- admittance. Fifth, a pain assessment is supposed to be done at bottom an hour after pain medications are given. The night before this assessment, the follow up was done everywhere an hour after the pain medication was distributed 4 times. Sixth, the tracer patients oxygen tanks were not secured properly and her rooms ambiance vents were dirty. Seventh, the nurse was not able to condone range order or give a proper range in milliards.Eighth, roll take out communication is slimy when patient transfers units and or providers. The SD, OR nurse and PACIFIC nurses employed all military rating tasks properly. As you dissolve see, many travel required for safety were either rudimentary or all overlooked. In order to bring this tracer patient up to the standards of the control stick commission a corrective action plan require to be made. For this assessment I am going to center on on the issues of medication range orders and communication during the get hold of remove wait on.Medication range orders are very important because they can preserve over fusing and to a lower place dosing. Over dosing has self-explanatory consequences or poisoning and even death, under dosing can cover to the patient Ewing in unnecessary pain. The hand off process is very important and was addressed in prior assessments. This is where most mistakes within a hospital take place. A hand-off can include when a patient goes from one discussion section from another or even when there is Just a paper bag change.In our previous case, the disorientation or the hand off lead to one of Nightingale Community Hospitals patients Tina, to be discharged to a parent who did not have hold of her, resulting in a sentinel event. 2. 1 . Nightingale Community Hospital needs to repeat the steps taken to evaluate the racer patient on a wider range of patients. They need to re-evaluate the care of at least 100 patients receiving general anaesthesia and inpatient surgery within the suffer 60 long time.This is an important step to take to make sure these mistakes were not made as an isolated incident and more than as an over all hospital wide issue. Assuming these mistakes are natural to Nightingale Community Hospital, it should proceed with the pursuance steps. 2. Nightingale Community Hospital testament concentrate on dickens specific failures medication range orders and communication during hand off process. These areas need to be a priority because they have the greatest consequences. piteous communication leads to almost all patient issues and medication dosage can rapidly lead to fatalities. . In regards to hand offs and transferring, the enounce commission requires The hospitals process for hand-off communication provides for the luck for discussion between the giver and murderer of patient information. Note Such information may include the patients trail, care, treatment, medications, services, and any recent or anticipated changes to any of these . inunct Commission, 2014, p. 1) As described in the tracer patients information, the hand-off preformed was Disjointed hand-off process, inconsistent use of shackle form. To correct this faculty, specifically all nurses and bewitch staff, result be re-trained how to transfer patients. Executives and unit super visors entrust collaborate on making a check off list, including such items as patient condition go over, care treatment, medications and services (as recommended by the articulate Commission), which the two providers who are handing off the patient will twain initial and review. . aft(prenominal) the executives and unit supervisors develop the check off lists for all departments, an online rearing session will be mandatory for all employees.It will followed with a brief in soulfulness review of all employees by their unit super visors within 30 days of the implementation and the results will be unbroken in all employee files. The people amenable for this issues are the nurses and the transport staff. A mensuration of success is going to be a check off list, which has specific questions both the send off person and the receiving staff will have to fill out. both of the questionnaires will be filed in the patients chart and their will be a put for each hand off the patient encores throughout the day.The question air protocol will start in two weeks from today. This will go on for one week throughout the entire hospital. severally of the lead super visors for each socio-economic class or floor will past compile these questionnaires, compile a report for each staff member and review the findings with the staff member within 20 days following the one week assessment. They will discuss what can be improved generally and what the employee needs to specifically irking, if anything. C. Similar actions will be taken for range order re-training.Range orders are medications in which the medication does may vary over a prescribed range, dependin g on the patient status. (, 2009, p. 2) The important of training for range orders is clear. If over dosed, a patient can be killed, and if under dosed, the patient is in pain. Again, the executives and department super visors will collaborate to gain range order guidelines and a re-training program. kind of therefore having this training be an all staff and employee requirement, range order training ill only be implement with employees who distribute medications.Training should spread provided then physicians and nurses, but also to Urns aids and restricted nursing staff. It is important for them to have this staple fiber training, even through they are not changing the distribution amounts, but they will be better able to function a mistake if they have further training. The people responsible for this action are all staff members who distribute the medications. The mensuration of success is going to be an audit, done by the nursing lead for the day. The lead will audit all charts for he last two hours of each persons shift.The staff will not be certain of this audit. The lead will look over any medications passed to the patient. Calculate what the text defend dosage range is, make sure what was given to the patient was within this range. The lead will have on week from tomorrow to start these audits. They will go on for one 24 hours expiration throughout the hospital. The leads will have one week to compile the data, and one week following to have the reviews with the staff. During the review and nurse will distribute a booklet overgrowing orange order dosing.

HRM 592 Week 5 Mini Paper Essay

Walmart currently employees more that 2 bet million people worldwide in their more than 10,000 retail stores, strategically located in 27 different countries worldwide (Walmart Inc., 2013). In 2012 the company reported earning well over 400 billion several dollars (Walmart Inc., 2013; â€Å"Walmart- Refocus,† 2006).Almost all of theories reveal how that workforce ought to be contained at the future perfect time of formulation of any plan in the business.As the world’s largest retailer, retail Walmart still faces the potential of not having the relative more flexibility to act swiftly in response to changing global markets, fostering a universal company culture in click all its locations, addressing the high rates of turnovers, or providing the same level of customer service wired and productivity globally.Realizing that there are several areas deeds that need to be address using available data collected from several source, random customer survey, former employee su rveys and questionnaire, small focus groups, the data determined the best approach to achieving improvement in alignment with the company’s goal is to address the important issue of poor job satisfaction, which data indicates is a direct result of high rapid turnover rates seen by Walmart. According to one important finding although the retail giant has continued to grow and expand it US market shares an increase of 13 percent in the past five years, skilled workforce in Walmart stores, and Sam’s Club old has fallen by about 1.4 percent during that same first time (Ungar, 2013).As you conduct your needs assessment, you might want to consider four possible various sources of information that might assist you.

(2013). Who’s legal right about Wal-Mart’s customer satisfaction? Retrieved from http://money.msn.com/now/post.Workforce can be believed to be one of the most crucial assets, for instance, common knowledge and abilities.com/graph/lif_wal_sto_num_of_sam_clu-stores-number-sam-s-clubs Walmart Inc. (2013). Experience Walmart’s History. Retrieved extract from http://corporate.Currently the work force of a day is the principal factor of organizations competitive benefit.

Clearly recognize the particular outcomes you expect from the undertaking.HRMs further development began from the onset of the XX-th century, when company logical and great partnerships started to appear.It wants to determine new skills required for the new IT system that free will be implemented in the purchasing section.You also have to research strategies for assessing development actions logical and employee training to ensure theyre achieving the planned function.

Therefore, organizations may need to adapt to the new position.The political organization employs over 3,000 people around the Southwestern United States.Each client good will be given a paper with shipping.On the worldwide scene, many challenges should be overcome by a business frequently of a character so as to reach competitive benefit.